2017 Sep;31(9):1330-1340. View abstract. View abstract. View abstract. Morris DJ, Davis E, Latif SA. Brush, J., Mendenhall, E., Guggenheim, A., Chan, T., Connelly, E., Soumyanath, A., Buresh, R., Barrett, R., and Zwickey, H. The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD69 expression and immune cell activation in humans. View abstract. Mamgain RK, Gupta M, Mamgain P, et al. I like herbal and fuit teas and a particular favourite of mine contains liquorice. Hum Exp Toxicol 2012;31(12):1295-1298. 4-14-2001;145(15):744-747. View abstract. Int Hepatol Comm 1997;233-238. Fan ZJ, Liu JM, Li XX, et al. [RETRACTED]. van den Bosch AE, van der Klooster JM, Zuidgeest DM, et al. View abstract. View abstract. 2007;30(10):1898-1904. Select a condition to view a list of vitamins. View abstract. Maeda T, Shinozuka K, Baba K, et al. Madisch A, Holtmann G, Mayr G, et al. One of its most known effects is the induction of hypertension, and it can induce what appears to be pseudohyperaldosteronism, due to glycyrrhetinic acid, the main active component of the root. View abstract. 2018;38(2):617-8. This Halloween, you'll want to stay vigilant about the candy . Cai Y, Yuan Q, Xu K, et al. Bai, Y. S., Zhou, C. Y., and Wang, J. Q. Little is known about whether it's safe to use licorice root while breastfeeding. View abstract. Learn more about Peony health benefits, uses, side effects, effectiveness, safety, precautions, and warnings. A., van Dokkum, W., and Savelkoul, T. J. Glycyrrhizic acid: the assessment of a no effect level. Comparative Study of the Effect of Licorice Muco-adhesive Film on Radiotherapy Induced Oral Mucositis, A Randomized Controlled Clinical Trial. Koo YK, Kim JM, Koo JY, et al. View abstract. View abstract. Bernardi, M., D'Intino, P. E., Trevisani, F., Cantelli-Forti, G., Raggi, M. A., Turchetto, E., and Gasbarrini, G. Effects of prolonged ingestion of graded doses of licorice by healthy volunteers. Zhong.Xi.Yi.Jie.He.Za Zhi. A dose of 800 milligrams (mg) or more of licorice root per day has been linked to low potassium levels. Chien, C. F., Wu, Y. T., and Tsai, T. H. Biological analysis of herbal medicines used for the treatment of liver diseases. Yoon JY, Cha JM, Hong SS, et al. (Glycyrrhiza glabra), it performs better, especially for relaxing muscles, reducing painful menstruation, as well as lowering serum and free testosterone levels in women with PCOS. An open study of 100 women with uterine fibroids showed that peony reduced the size of . Effects of the Japanese herbal medicine "Sho-saiko-to" (TJ-9) on in vitro interleukin-10 production by peripheral blood mononuclear cells of patients with chronic hepatitis C. Hepatology 1997;25(6):1390-1397. View abstract. A controlled trial of traditional Chinese herbal medicine in Chinese patients with recalcitrant atopic dermatitis. View abstract. Deglycyrrhizinated liquorice in aphthous ulcers. Kamei T, Kumano H, Iwata K, et al. Liang, R., Chen, M. R., and Xu, X. Werner, S., Brismar, K., and Olsson, S. Hyperprolactinaemia and liquorice. View abstract. Effect of Japanese Angelica root and peony root on uterine contraction in the rabbit in situ. Melzer J, Rosch W, Reichling J, et al. View abstract. Petramfar P, Hajari F, Yousefi G, Azadi S, Hamedi A. Efficacy of oral administration of licorice as an adjunct therapy on improving the symptoms of patients with Parkinson's disease, A randomized double blinded clinical trial. View abstract. B. Licorice-associated reversible cerebral vasoconstriction with PRES. Kang, J. H., Park, Y. H., Choi, S. W., Yang, E. K., and Lee, W. J. Resveratrol derivatives potently induce apoptosis in human promyelocytic leukemia cells. Acta Endocrinol (Buchar) 2020;16(4):508-510. J Nat Prod 1980;43(2):259-269. O'Connell K, Kinsella J, McMahon C, Holian J, O'Riordan S. Posterior reversible encephalopathy syndrome (PRES) associated with liquorice consumption. B., and Zhang, Z. J. Exp Ther Med 2016;11(3):1135-41. Licorice might increase blood pressure. Tu, J. H., He, Y. J., Chen, Y., Fan, L., Zhang, W., Tan, Z. R., Huang, Y. F., Guo, D., Hu, D. L., Wang, D., and Hong-Hao Zhou. Complement Ther Med. Badr, A. E., Omar, N., and Badria, F. A. View abstract. The chemicals in licorice are thought to . Liang, R. N., Liu, J., and Lu, J. Mohire, N. C. and Yadav, A. V. Chitosan-based polyherbal toothpaste: as novel oral hygiene product. Pfeifer BL, Pirani JF, Hamann SR, Klippel KF. Patel P, Aknouk M, Dawson A, et al. The sweet stuff in your kids' trick-or-treat buckets may come with a bitter side effect. Ohta H, Ni JW, Matsumoto K, et al. Kwon S, Jin C, Cho SY, et al. Sheth, V. M. and Pandya, A. G. Melasma: a comprehensive update: part II. Eur J Obstet Gynecol.Reprod Biol 2007;131(1):61-67. Anesth Analg. Vestn.Dermatol.Venerol. Zhang XH, Lowe D, Giles P, et al. Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Altern Med Rev 1999;4(3):178-188. Nasal irrigation with Glycyrrhiza glabra extract for treatment of allergic rhinitis - A study of in vitro, in vivo and clinical trial. Monitor your blood pressure closely. Effects of paeoniflorin on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of transient middle cerebral artery occlusion in rats. Note: Results may vary from person to person, depending on the skin type. Pak J Med Sci 2022;38(1):271-275. Gallacher SD, Tsokolas G, Dimitropoulos I. Liquorice-induced apparent mineralocorticoid excess presenting in the emergency department. Attou R, Redant S, Honore PM, Preseau T, Hantson P, De Bels D. Liquorice intoxication can lead to cardiac arrest! Phytother Res. Leem, K., Kim, H., Boo, Y., Lee, H. S., Kim, J. S., Yoo, Y. C., Ahn, H. J., Park, H. J., Seo, J. C., Kim, H. K., Jin, S. Y., Park, H. K., Chung, J. H., and Cho, J. J. Middle East J Anaesthesiol. A controlled trial of traditional Chinese medicinal plants in widespread non-exudative atopic eczema. 2003;84(1):85-89. Lee, S. M., Li, M. L., Tse, Y. C., Leung, S. C., Lee, M. M., Tsui, S. K., Fung, K. P., Lee, C. Y., and Waye, M. M. Paeoniae Radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway. Taking licorice might reduce the effects of blood pressure medications. Warfarin is used to slow blood clotting. BMJ Case Rep. 2012 Oct 19;2012. Drugs & Vitamins . Am J Chin Med 2003;31:445-53. . Another type of licorice, called DGL or deglycyrrhizinated licorice, does not seem to have the same side effects and is sometimes used to treat peptic ulcers, canker sores, and reflux (GERD). Yamada, K., Kanba, S., Yagi, G., and Asai, M. Effectiveness of herbal medicine (shakuyaku-kanzo-to) for neuroleptic-induced hyperprolactinemia. Phytother Res 2008;22:563-5. A., Ziaee, A., and Samimi, R. The efficacy of licorice root extract in decreasing transaminase activities in non-alcoholic fatty liver disease: a randomized controlled clinical trial. J Pharmacobiodyn 1984;7:304-11. A pilot study. Schweiz Med Wochenschr 2-26-1977;107(8):276-279. View abstract. 17. J Ethnopharmacol. Zhong.Xi.Yi.Jie.He.Za Zhi. View abstract. Medicine (Baltimore) 2019;98(35):e16601. Red Peony Root (Paeniae Rubra Radix) 8 g Myrrh (Myrrha) . Francini-Pesenti F, Puato M, Piccoli A, Brocadello F. Liquorice-induced hypokalaemia and water retention in the absence of hypertension. Helpful. Kraus SD, Kaminskis A. Acute myopathy associated with chronic licorice ingestion: reversible loss of myoadenylate deaminase activity. Liu X, Li X, Li X, et al. Blood Press 2009;18:192-5. Eyi, E. G., Engin-Ustun, Y., Kaba, M., and Mollamahmutoglu, L. Ankaferd blood stopper in episiotomy repair. Taking peony along with birth control pills might increase the risk of side effects. For people who already have high blood pressure or heart or kidney disease, as little as 5 g/day can cause these side effects. 2 in the perioperative stage of laparoscopic cholecystectomy]. Fujisawa, Y., Sakamoto, M., Matsushita, M., Fujita, T., and Nishioka, K. Glycyrrhizin inhibits the lytic pathway of complement--possible mechanism of its anti-inflammatory effect on liver cells in viral hepatitis. Immunology 1997;90(1):115-120. [Clinical study on treatment of mid-advanced crescentic nephritis by qingre huoxue recipe]. 2019;38(3):657-64. Sun, W. S., Imai, A., Tagami, K., Sugiyama, M., Furui, T., and Tamaya, T. In vitro stimulation of granulosa cells by a combination of different active ingredients of unkei-to. Rosenblat, M. and Aviram, M. Paraoxonases role in the prevention of cardiovascular diseases. Med Princ Pract 2010;19(6):485-489. Hawrelak, J. The roots are commonly used in Traditional Chinese Medicine (TCM) for many purposes. Effect of deglycyrrhizinated liquorice on gastric mucosal damage by aspirin. Birth outcome in relation to licorice consumption during pregnancy. Bruynzeel DP. Davis EA, Morris DJ. Chemical studies of Chinese licorice-roots. View abstract. An evaluation of the efficacy of licorice gargle for attenuating postoperative sore throat: a prospective, randomized, single-blind study. Biol Pharm Bull 1998;21:1277-81. Imtiaz, K. E. Sweet root, bitter pill: liquorice-induced hyperaldosteronism. Exp Neurol 1997;146:518-25. Wong, A. L. and Chan, T. Y. Interaction between warfarin and the herbal product quilinggao. Int J Environ Res Public Health 2021;19(1):242. View abstract. Indian J Med Res 1993;98:69-74. Effects of cerebral ischemia-reperfusion on pharmacokinetic fate of paeoniflorin after intravenous administration of Paeoniae Radix extract in rats. Sigurjonsdottir, H. A., Manhem, K., Axelson, M., and Wallerstedt, S. Subjects with essential hypertension are more sensitive to the inhibition of 11 beta-HSD by liquorice. Turpie AG, Runcie J, Thomson TJ. Postgrad Med 2017;129(3):329-31. Large amounts of licorice can decrease potassium levels in the body. Thom E and Wollan T. A controlled clinical study of kanjang mixture in the treatment of uncomplicated upper respiratory tract infections. Alt Med Rev 2001;6:495-9. Arentz S, Smith CA, Abbott J, Fahey P, Cheema BS, Bensoussan A. J Cancer Res Ther. Isr J Dent Sci 1989;2(3):153-157. . View abstract. View abstract. 2009;14(1):64-65. Koster, M. and David, G. K. Reversible severe hypertension due to licorice ingestion. Peony-glycyrrhiza decoction, an herbal preparation, inhibits clozapine metabolism via cytochrome P450s, but not flavin-containing monooxygenase in in vitro models. Licorice is Sita (cold) in nature, Guru (heavy) to digest, and Madhura (sweet) in . View abstract. 1991;78(1-2):1-6. Report of a new case]. Rev Med Brux 2008;29(5):490-493. Zhou Y, Jin L, Kong F, et al. View abstract. Hinoshita F, Ogura Y, Suzuki Y, et al. Medically reviewed by Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT By Kirsten Nunez on October 16, 2020. Liquorice and hypertension. Cumming, A. M., Boddy, K., Brown, J. J., Fraser, R., Lever, A. F., Padfield, P. L., and Robertson, J. I. Lancet 2000;355(9198):134-138. Ital J Neurol Sci 1983;4(4):493-497. View abstract. A. Baykul, T., Alanoglu, E. G., and Kocer, G. Use of Ankaferd Blood Stopper as a hemostatic agent: a clinical experience. View abstract. View abstract. Paeoniflorin, a constituent of white peony root, has demonstrated inhibition of testosterone synthesis in vitro, without affecting estradiol synthesis.It reduces testosterone production by the ovaries but not the adrenal glands. and its bioactive compounds. Chen, W. G. and Ba, Z. M. Prof. ZHANG Yi's experience in treating severe arrhythmia. It is used for stomach pain, abdominal pain and acute pain of gastrocnemius muscle contracture, etc. View abstract. View abstract. If you take birth control pills along with peony, use an additional form of birth control such as a condom. View abstract. Lee, C. H., Park, S. W., Kim, Y. S., Kang, S. S., Kim, J. View abstract. Armanini D, Bonanni G, Mattarello MJ, et al. Licorice root and white peony for PCOS. Z Gastroenterol 2001;39(7):511-7. Armanini D, De Palo CB, Mattarello MJ, et al. Lin SH, Yang SS, Chau T, Halperin ML. View abstract. Licorice root contains glycyrrhizin, which can cause side effects when eaten in large amounts. Lapi F, Gallo E, Bernasconi S, et al. Barrella, M., Lauria, G., Quatrale, R., and Paolino, E. Hypokaliemic rhabdomyolysis associated with liquorice ingestion: report of an atypical case. View abstract. View abstract. Chen, M. F., Shimada, F., Kato, H., Yano, S., and Kanaoka, M. Effect of oral administration of glycyrrhizin on the pharmacokinetics of prednisolone. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Taking licorice with paclitaxel might decrease the effects of paclitaxel. Eur.Arch.Paediatr.Dent 2010;11(6):274-278. Assessment of the therapeutic effect of total glycosides of peony for juvenile idiopathic arthritis: a systematic review and meta-analysis. Russo S, Mastropasqua M, Mosetti MA, et al. World J Gastroenterol 2-7-2006;12(5):760-764. Phytother.Res. Feng Z, Xu J, He G, et al. A preliminary open trial on interferon stimulator (SNMC) derived from Glycyrrhiza glabra in the treatment of subacute hepatic failure. Combined Lifestyle and Herbal Medicine in Overweight Women with Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial. 2017 Apr 1;27(2):150-154. doi: 10.1684/ejd.2016.2946. Phytother Res. But the potential side effects are real enough. Lancet 1992;340:13-17. J Clin Psychopharmacol 2016;36(6):572-9. Ed. Nishioka, K. and Seguchi, T. Contact allergy due to oil-soluble licorice extracts in cosmetic products. View abstract. Z., Zhang, Y. J Clin Psychopharmacol 1997;17(3):234-235. 2020;383(13):1263-1275. 2019;18(Suppl1):291-301. After lab testing, the Cheng team found that Huang Qin Tang had a high inhibitory property against the debilitating side effects of a chemotherapy drug called CPT-11 (later approved as irinotecan), including diarrhea, nausea, and vomiting. This plant is native to East Asia. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Dellow EL, Unwin RJ, Honour JW. Peony and Licorice is a safe and gentle yet powerful formula that is famous for its ability to build blood and balance menstrual cycles. Izv Akad Nauk Ser Biol 1997;2:235-7. . Peony (Paeonia lactiflora) is an herb. View abstract. The efficacy of an ayurvedic preparation of yashtimadhu (Glycyrrhiza glabra) on radiation-induced mucositis in head-and-neck cancer patients: A pilot study. Nabeshima, S., Kashiwagi, K., Ajisaka, K., Masui, S., Takeoka, H., Ikematsu, H., and Kashiwagi, S. A randomized, controlled trial comparing traditional herbal medicine and neuraminidase inhibitors in the treatment of seasonal influenza. A comparison of carbenoxolone sodium and deglycyrrhizinated liquorice in the treatment of gastric ulcer in the ambulant patient. Complement Ther Clin Pract. Contact Dermatitis 2021;85(4):454-455. Hajiaghamohammadi AA, Zargar A, Oveisi S, Samimi R, Reisian S. To evaluate of the effect of adding licorice to the standard treatment regimen of Helicobacter pylori. Rackova, L., Jancinova, V., Petrikova, M., Drabikova, K., Nosal, R., Stefek, M., Kostalova, D., Pronayova, N., and Kovacova, M. Mechanism of anti-inflammatory action of liquorice extract and glycyrrhizin. J Hum Hypertens 1995;9:345-8. [Treatment of refractory polycystic ovary syndrome by bushen huoxue method combined with ultrasound-guided follicle aspiration]. Peony root might decrease the amount of phenytoin in the body. J Endocrinol Invest 2003;26:646-50. PC-SPES, a dietary supplement for the treatment of hormone-refractory prostate cancer. BJU Int 2000;85:481-5. It may disrupt the production of sex hormones ( 9 ). View abstract. Huang, W. W., Wang, M. Y., Shi, H. M., Peng, Y., Peng, C. S., Zhang, M., Li, Y., Lu, J., and Li, X. This can be severe. Hussain RM. (Doses up to 60 grams daily for up to 4 months have been used without reported adverse effects.) ['Licorice hypertension' also caused by licorice tea]. Effects of mouthwash interventions on xerostomia and unstimulated whole saliva flow rate among hemodialysis patients: a randomized controlled study. Gatica-Ortega ME, Pastor-Nieto MA. Brit Med J 1952;1:360-361. View abstract. View abstract. Because children's skin is soft and tender, more sufficient data on side effects such as allergies or burns, are needed. Tooth decay. View abstract. Rees, W. D., Rhodes, J., Wright, J. E., Stamford, L. F., and Bennett, A. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Sato H, Goto W, Yamamura J, et al. J Clin Psychopharmacol 2016;36(6):572-9. Biol Pharm Bull 2000;23:199-203.. View abstract. The sweet cake that reaches parts other cakes can't! Man SC, Li XB, Wang HH, et al. View abstract. Zangooei Pourfard M, Mirmoosavi SJ, Beiraghi Toosi M, et al. A Rutgers expert discusses how eating black licorice can affect your health. Amato P, Christophe S, Mellon PL. Licorice seems to change hormone levels in the body. View abstract. View abstract. Lancet 1990;335(8697):1060-3. Peony might have some of the same effects as estrogen. Yu C, Fan X, Li Z, Liu X, Wang G. Efficacy and safety of total glucosides of paeony combined with acitretin in the treatment of moderate-to-severe plaque psoriasis: a double-blind, randomised, placebo-controlled trial. de Klerk GJ, Nieuwenhuis G, Beutler JJ. View abstract. Br J Clin Pract 1972;26(12):563-566. CJEM 2009;11(1):94-96. Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats. CJEM 2010;12(3):224-225. Clin Pharmacol Ther 1996;59:62-71. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Hossain, M. S., Takimoto, H., Hamano, S., Yoshida, H., Ninomiya, T., Minamishima, Y., Kimura, G., and Nomoto, K. Protective effects of hochu-ekki-to, a Chinese traditional herbal medicine against murine cytomegalovirus infection. This versatile anti-inflammatory plant can benefit digestive issues, hormone health, and skin health as well as helping ease problems with menstruation and menopause. Effect of glycyrrhizin-containing toothpaste on dental plaque reduction and gingival health in humans. A specific type of peony product, total glucosides of peony (TGP), has most often been used by adults in doses of 600 mg by mouth three times daily for up to 24 weeks. Anesth Analg 2009;109(1):77-81. Zhang W, Dai SM. A controlled trial of a dissolving oral patch concerning glycyrrhiza (licorice) herbal extract for the treatment of aphthous ulcers. Br Med J 1971;3(773):501-503. Also for White Peony, the plant that is used in traditional . Cotterill, J. J Clin Anesth 2019;54:25-32. Steroids 2005;70(8):538-542. A 2020 review found that licorice root extract can help reduce the growth of . Cochrane Database Syst Rev 2004;4:CD002291. No negative side effects. View abstract.